Human Kindlin 2 (FERMT2) (NM_006832) Protein

Price:20 μg￥2,900.00 ; 100 μg￥9,998.00 ; 1 mg￥36,000.00

SKU: PME33165 Category: ECD Proteins

Target	Kindlin 2
Synonyms	KIND2; mig-2; MIG2; PLEKHC1; UNC112; UNC112B
Description	Recombinant protein of human fermitin family homolog 2 (Drosophila) (FERMT2), transcript variant 1
Delivery	2-3 weeks
Uniprot ID	Q96AC1
Expression Host	HEK293T
Tag	C-Myc/DDK
Molecular Characterization	N/A
Molecular Weight	77.7 kDa
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Formulation & Reconstitution	25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Storage & Shipping	Store at -80°C.
Background	Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.[UniProtKB/Swiss-Prot Function]
Usage	Research use only
Conjugate	Unconjugated