Human HTR6 Protein, hFc Tag

HTR6 encodes the 5-hydroxytryptamine (serotonin) receptor 6, a G-protein coupled receptor (GPCR) that primarily couples to Gs proteins, leading to activation of adenylyl cyclase and elevation of intracellular cAMP levels. It is mainly expressed in the central nervous system, particularly in the striatum, cortex, hippocampus, and olfactory tubercle, where it modulates cholinergic, dopaminergic, and glutamatergic neurotransmission. HTR6 plays important roles in cognition, learning, memory, and mood regulation. Dysregulation of HTR6 signaling has been implicated in Alzheimer’s disease, schizophrenia, and cognitive impairment, making it a potential therapeutic target for neuropsychiatric and neurodegenerative disorders.