Human ATRX (NM_000489) Protein

Price:50 μg￥1,950.00 ;

SKU: PME49151 Category: ECD Proteins

Target	ATRX
Synonyms	JMS; MRX52; RAD54; RAD54L; XH2; XNP; ZNF-HX
Description	Purified recombinant protein of Human alpha thalassemia/mental retardation syndrome X-linked (ATRX), transcript variant 1, Leu908-Thr1068, with N-terminal His tag, expressed in E.coli, 50ug
Delivery	1 week
Uniprot ID	P46100
Expression Host	E. coli
Tag	N-His
Molecular Characterization	N/A
Molecular Weight	18.3 kDa
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Formulation & Reconstitution	25mM Tris, pH8.0, 150mM NaCl, 10% glycerol
Storage & Shipping	Store at -80°C after receiving vials.
Background	The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]
Usage	Research use only
Conjugate	Unconjugated