Human LYK5 (STRADA) (NM_153335) Protein

Price:50 μg￥2,040.00 ;

SKU: PME47218 Category: ECD Proteins

Target	LYK5
Synonyms	LYK5; NY-BR-96; PMSE; Stlk; STRAD; STRAD alpha
Description	Purified recombinant protein of Homo sapiens STE20-related kinase adaptor alpha (STRADA), transcript variant 3, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Delivery	2-3 weeks
Uniprot ID	Q7RTN6
Expression Host	E. coli
Tag	N-His
Molecular Characterization	N/A
Molecular Weight	38.4 kDa
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Formulation & Reconstitution	25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl
Storage & Shipping	Store at -80°C.
Background	The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]
Usage	Research use only
Conjugate	Unconjugated