Human PXR (NR1I2) (NM_003889) Protein

Price:20 μg￥2,900.00 ; 100 μg￥9,998.00 ; 1 mg￥36,000.00

SKU: PME33148 Category: ECD Proteins

Target	PXR
Synonyms	BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR
Description	Recombinant protein of human nuclear receptor subfamily 1, group I, member 2 (NR1I2), transcript variant 1
Delivery	2-3 weeks
Uniprot ID	O75469
Expression Host	HEK293T
Tag	C-Myc/DDK
Molecular Characterization	N/A
Molecular Weight	49.6 kDa
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Formulation & Reconstitution	25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Storage & Shipping	Store at -80°C.
Background	This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
Usage	Research use only
Conjugate	Unconjugated