Human 5HT2A full length protein-synthetic nanodisc

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SKU: FLP100166 Category: Full Length Transmembrane Proteins

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Tag	C-Flag Tag
Target	5HT2A
Synonyms	5-HT2A, HTR2
Description	Human 5HT2A full length protein-synthetic nanodisc
Delivery	6~8weeks
Uniprot ID	P28223
Expression Host	HEK293
Protein Families	GPCR,Transmembrane,Druggable Genome,
Protein Pathways	GPCRDB Class A Rhodopsin-like,GPCRDB Other,Monoamine GPCRs,Metabolic and Obesity,
Molecular Weight	The human full length 5HT2A protein has a MW of 52.6kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Usage	Research use only
Conjugate	Unconjugated

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